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A novel air sampling and analytical method for determination of airborne bronopol

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Material Information

Title:
A novel air sampling and analytical method for determination of airborne bronopol
Physical Description:
Book
Language:
English
Creator:
Smyth, John Charles
Publisher:
University of South Florida
Place of Publication:
Tampa, Fla
Publication Date:

Subjects

Subjects / Keywords:
Fungi
Indoor environmental quality
Contact dermatitis
Allergy
Asthma
Dissertations, Academic -- Public Health -- Doctoral -- USF
Genre:
bibliography   ( marcgt )
theses   ( marcgt )
non-fiction   ( marcgt )

Notes

Abstract:
ABSTRACT: Bronopol has been used as a preservative in drugs and cosmetics since 1964. Bronopol has low dermal irritancy at levels commonly used in cosmetics and pharmaceuticals but it is significantly irritating at higher concentrations. Laboratory testing of bronopol indicates a low potential for dermal sensitization; however, a number of case reports demonstrate human allergenic reactions. No reports were identified on the allergenic properties of bronopol for the inhalation route of exposure. In 1983 approximately 5,200 people in the United States were occupationally exposed to bronopol. Current novel uses of bronopol include mold remediation and the sanitizing of ventilation system components. These new applications have the potential to expose vast new populations to the chemical. Since 89 million people in the United States work in indoor environments and 50 million Americans suffer from allergies, it is likely that a sizeable portion of these populations will be exposed^ to bronopol. This is significant since the dermal sensitizing properties of bronopol suggest that the material may also be a respiratory sensitizer, potentially resulting in chemically induced asthma. More people are being diagnosed with asthma today than at any time in the past; the causes of this increased prevalence are largely unknown. In this work an existing ultraviolet spectrophotometric method for analysis of bronopol has been combined with conventional industrial hygiene air sampling techniques. No combined air sampling and analytical method for bronopol has previously been published in the literature. A calibration curve has been developed with a linear range of 1 ug/ml to 25 ug/ml. The instrumental limit of detection is 1 ug/ml with an instrumental limit of quantitation of ca. 3 ug/ml. During chamber sampling trials analytical recovery for treated glass fiber filters yielded a sampling recovery efficiency averaging 99.9 %. Bronopol concentration obtained during chamber ^sampling trials ranged from 10.80 mg/m3 to 21.59 mg/m3, with a pooled coefficient of variation of 4.33 % for all chamber sampling sets. Treated glass fiber filters spiked with bronopol were found to be stable for a period of 48 hours; derivatized bronopol solutions were found to be stable for a period of fourteen days.
Thesis:
Dissertation (Ph.D.)--University of South Florida, 2006.
Bibliography:
Includes bibliographical references.
System Details:
System requirements: World Wide Web browser and PDF reader.
System Details:
Mode of access: World Wide Web.
Statement of Responsibility:
by John Charles Smyth.
General Note:
Title from PDF of title page.
General Note:
Document formatted into pages; contains 179 pages.
General Note:
Includes vita.

Record Information

Source Institution:
University of South Florida Library
Holding Location:
University of South Florida
Rights Management:
All applicable rights reserved by the source institution and holding location.
Resource Identifier:
aleph - 001914262
oclc - 175291754
usfldc doi - E14-SFE0001744
usfldc handle - e14.1744
System ID:
SFS0026062:00001


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RA425 (ONLINE)
1 100
Smyth, John Charles.
2 245
A novel air sampling and analytical method for determination of airborne bronopol
h [electronic resource] /
by John Charles Smyth.
260
[Tampa, Fla] :
b University of South Florida,
2006.
3 520
ABSTRACT: Bronopol has been used as a preservative in drugs and cosmetics since 1964. Bronopol has low dermal irritancy at levels commonly used in cosmetics and pharmaceuticals but it is significantly irritating at higher concentrations. Laboratory testing of bronopol indicates a low potential for dermal sensitization; however, a number of case reports demonstrate human allergenic reactions. No reports were identified on the allergenic properties of bronopol for the inhalation route of exposure. In 1983 approximately 5,200 people in the United States were occupationally exposed to bronopol. Current novel uses of bronopol include mold remediation and the sanitizing of ventilation system components. These new applications have the potential to expose vast new populations to the chemical. Since 89 million people in the United States work in indoor environments and 50 million Americans suffer from allergies, it is likely that a sizeable portion of these populations will be exposed^ to bronopol. This is significant since the dermal sensitizing properties of bronopol suggest that the material may also be a respiratory sensitizer, potentially resulting in chemically induced asthma. More people are being diagnosed with asthma today than at any time in the past; the causes of this increased prevalence are largely unknown. In this work an existing ultraviolet spectrophotometric method for analysis of bronopol has been combined with conventional industrial hygiene air sampling techniques. No combined air sampling and analytical method for bronopol has previously been published in the literature. A calibration curve has been developed with a linear range of 1 ug/ml to 25 ug/ml. The instrumental limit of detection is 1 ug/ml with an instrumental limit of quantitation of ca. 3 ug/ml. During chamber sampling trials analytical recovery for treated glass fiber filters yielded a sampling recovery efficiency averaging 99.9 %. Bronopol concentration obtained during chamber ^sampling trials ranged from 10.80 mg/m3 to 21.59 mg/m3, with a pooled coefficient of variation of 4.33 % for all chamber sampling sets. Treated glass fiber filters spiked with bronopol were found to be stable for a period of 48 hours; derivatized bronopol solutions were found to be stable for a period of fourteen days.
502
Dissertation (Ph.D.)--University of South Florida, 2006.
504
Includes bibliographical references.
516
Text (Electronic dissertation) in PDF format.
538
System requirements: World Wide Web browser and PDF reader.
Mode of access: World Wide Web.
500
Title from PDF of title page.
Document formatted into pages; contains 179 pages.
Includes vita.
590
Adviser: Yehia Y. Hammad, Sc.D.
653
Fungi.
Indoor environmental quality.
Contact dermatitis
Allergy
Asthma
690
Dissertations, Academic
z USF
x Public Health
Doctoral.
773
t USF Electronic Theses and Dissertations.
4 0 856
u http://digital.lib.usf.edu/?e14.1744