Citation

Material Information

Title:
Prevalence and genetic diversity of coronaviruses in bats from China
Series Title:
Journal of Virology
Creator:
Tang, X. C.
Zhang, J.X.
Zhang, S.Y.
Wang, P.
Fan, X.H.
Li, L.F.
Li, G.
Dong, B.Q.
Liu, W.
Cheung, C.L.
Xu, K.M.
Song, W.J.
Vijaykrishna, D.
Poon, L.L.M.
Peiris, J.S.M.
Smith, G.J.D.
Chen, H.
Guan, Y.
Publisher:
American Society for Microbiology
Publication Date:
Physical Description:
1 online resource

Subjects

Subjects / Keywords:
Bats -- China ( lcsh )
Coronaviruses ( lcsh )
SARS (Disease) ( lcsh )
Genre:
serial ( sobekcm )
Location:
Asia -- China

Notes

Abstract:
Coronaviruses can infect a variety of animals including poultry, livestock, and humans and are currently classified into three groups. The interspecies transmissions of coronaviruses between different hosts form a complex ecosystem of which little is known. The outbreak of severe acute respiratory syndrome (SARS) and the recent identification of new coronaviruses have highlighted the necessity for further investigation of coronavirus ecology, in particular the role of bats and other wild animals. In this study, we sampled bat populations in 15 provinces of China and reveal that approximately 6.5% of the bats, from diverse species distributed throughout the region, harbor coronaviruses. Full genomes of four coronavirues from bats were sequenced and analyzed. Phylogenetic analyses of the spike, envelope, membrane, and nucleoprotein structural proteins and the two conserved replicase domains, putative RNA-dependent RNA polymerase and RNA helicase, revealed that bat coronaviruses cluster in three different groups: group 1, another group that includes all SARS and SARS-like coronaviruses (putative group 4), and an independent bat coronavirus group (putative group 5). Further genetic analyses showed that different species of bats maintain coronaviruses from different groups and that a single bat species from different geographic locations supports similar coronaviruses. Thus, the findings of this study suggest that bats may play an integral role in the ecology and evolution of coronaviruses.
Original Version:
Volume 80, Issue 15

Record Information

Source Institution:
University of South Florida
Holding Location:
University of South Florida
Rights Management:
All applicable rights reserved by the source institution and holding location.
Resource Identifier:
K26-05406 ( USFLDC DOI )
k26.5406 ( USFLDC Handle )

USFLDC Membership

Aggregations:
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Postcard Information

Format:
Serial