Isolation and characterization of a novel bat coronavirus closely related to the direct progenitor of Severe Acute Respiratory Syndrome coronavirus

Citation

Material Information

Title:
Isolation and characterization of a novel bat coronavirus closely related to the direct progenitor of Severe Acute Respiratory Syndrome coronavirus
Series Title:
Journal of virology
Creator:
Yang, Xing-Lou
Hu, Ben
Wang, Bo
Wang, Mei-Niang
Zhang, Qian
Zhang, Wei
Wu, Li-Jun
Ge, Xing-Yi
Zhang, Yun-Zhi
Daszak, Peter
Wang, Lin-Fa
Shi, Zheng-Li
Publisher:
American Society for Microbiology
Publication Date:

Subjects

Subjects / Keywords:
Coronaviruses ( lcsh )
SARS (Disease) ( lcsh )
Bats -- Viruses ( lcsh )
Genre:
serial ( sobekcm )

Notes

Abstract:
We report the isolation and characterization of a novel bat coronavirus which is much closer to the severe acute respiratory syndrome coronavirus (SARS-CoV) in genomic sequence than others previously reported, particularly in its S gene. Cell entry and susceptibility studies indicated that this virus can use ACE2 as a receptor and infect animal and human cell lines. Our results provide further evidence of the bat origin of the SARS-CoV and highlight the likelihood of future bat coronavirus emergence in humans.
Original Version:
Volume 90, Issue 6

Record Information

Source Institution:
University of South Florida
Holding Location:
University of South Florida
Rights Management:
All applicable rights reserved by the source institution and holding location.
Resource Identifier:
K26-05411 ( USFLDC DOI )
k26.5411 ( USFLDC Handle )

USFLDC Membership

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serial

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