Full-length genome sequences of two SARS-like coronaviruses in horseshoe bats and genetic variation analysis

Citation

Material Information

Title:
Full-length genome sequences of two SARS-like coronaviruses in horseshoe bats and genetic variation analysis
Series Title:
Journal of general virology
Creator:
Ren, Wuze
Li, Wendong
Yu, Meng
Hao, Pei
Zhang, Yuan
Zhou, Peng
Zhang, Shuyi
Zhao, Guoping
Zhong, Yang
Wang, Shengyue
Wang, Lin-Fa
Shi, Zhengli
Publisher:
Microbiology Society
Publication Date:
Physical Description:
1 online resource

Subjects

Subjects / Keywords:
Coronaviruses ( lcsh )
Bats -- Viruses ( lcsh )
SARS (Disease) ( lcsh )
Genre:
serial ( sobekcm )

Notes

Abstract:
Bats were recently identified as natural reservoirs of SARS-like coronavirus (SL-CoV) or SARS coronavirus-like virus. These viruses, together with SARS coronaviruses (SARS-CoV) isolated from human and palm civet, form a distinctive cluster within the group 2 coronaviruses of the genus Coronavirus, tentatively named group 2b (G2b). In this study, complete genome sequences of two additional group 2b coronaviruses (G2b-CoVs) were determined from horseshoe bat Rhinolophus ferrumequinum (G2b-CoV Rf1) and Rhinolophus macrotis (G2b-CoV Rm1). The bat G2b-CoV isolates have an identical genome organization and share an overall genome sequence identity of 88–92 % among themselves and between them and the human/civet isolates. The most variable regions are located in the genes encoding nsp3, ORF3a, spike protein and ORF8 when bat and human/civet G2b-CoV isolates are compared. Genetic analysis demonstrated that a diverse G2b-CoV population exists in the bat habitat and has evolved from a common ancestor of SARS-CoV.
Original Version:
Volume 87

Record Information

Source Institution:
University of South Florida
Holding Location:
University of South Florida
Rights Management:
All applicable rights reserved by the source institution and holding location.
Resource Identifier:
K26-05412 ( USFLDC DOI )
k26.5412 ( USFLDC Handle )

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