Bat severe acute respiratory syndrome-like coronavirus ORF3b homologues display different interferon antagonist activities

Citation

Material Information

Title:
Bat severe acute respiratory syndrome-like coronavirus ORF3b homologues display different interferon antagonist activities
Series Title:
Journal of general virology
Creator:
Zhou, Peng
Li, Hongxia
Wang, Hanzhong
Wang, Lin-Fa
Shi, Zhengli
Publisher:
Microbiology Society
Publication Date:
Physical Description:
1 online resource

Subjects

Subjects / Keywords:
Coronaviruses ( lcsh )
SARS (Disease) ( lcsh )
Bats -- Viruses ( lcsh )
Genre:
serial ( sobekcm )

Notes

Abstract:
The ORF3b protein of severe acute respiratory syndrome coronavirus (SARS-CoV) has a nuclear localization signal (NLS) at its C terminus and antagonizes interferon (IFN) function by modulating the activity of IFN regulatory factor 3 (IRF3). SARS-like coronaviruses (SL-CoVs) found in bats share an identical genome organization and high sequence identity for most of their gene products. In this study, ORF3b homologues were identified from three bat SL-CoV strains. These ORF3b homologues were C-terminally truncated and lacked the C-terminal NLS of SARS-CoV. IFN antagonist activities analysis demonstrated that one SL-CoV ORF3b still possessed IFN antagonist and IRF3-modulating activities. These results indicate that different ORF3b proteins display different IFN antagonist activities and this function is independent of the protein’s nuclear localization, suggesting a potential link between bat SL-CoV ORF3b function and viral pathogenesis.
Original Version:
Volume 93

Record Information

Source Institution:
University of South Florida
Holding Location:
University of South Florida
Rights Management:
All applicable rights reserved by the source institution and holding location.
Resource Identifier:
K26-05438 ( USFLDC DOI )
k26.5438

USFLDC Membership

Aggregations:
University of South Florida
Karst Information Portal

Postcard Information

Format:
serial

printinsert_linkshareget_appmore_horiz

Download Options [CUSTOM IMAGE]

close
No images are available for this item.
Cite this item close

APA

Cras ut cursus ante, a fringilla nunc. Mauris lorem nunc, cursus sit amet enim ac, vehicula vestibulum mi. Mauris viverra nisl vel enim faucibus porta. Praesent sit amet ornare diam, non finibus nulla.

MLA

Cras efficitur magna et sapien varius, luctus ullamcorper dolor convallis. Orci varius natoque penatibus et magnis dis parturient montes, nascetur ridiculus mus. Fusce sit amet justo ut erat laoreet congue sed a ante.

CHICAGO

Phasellus ornare in augue eu imperdiet. Donec malesuada sapien ante, at vehicula orci tempor molestie. Proin vitae urna elit. Pellentesque vitae nisi et diam euismod malesuada aliquet non erat.

WIKIPEDIA

Nunc fringilla dolor ut dictum placerat. Proin ac neque rutrum, consectetur ligula id, laoreet ligula. Nulla lorem massa, consectetur vitae consequat in, lobortis at dolor. Nunc sed leo odio.