A High-Coverage Genome Sequence from an Archaic Denisovan Individual


Material Information

A High-Coverage Genome Sequence from an Archaic Denisovan Individual
Series Title:
Meyer, Matthias
Kircher, Martin
Gansauge, Marie-Theres
Li, Heng
Racimo, Fernando
Mallick, Swapan
Schraiber, Joshua G.
Jay, Flora
Prüfer, Kay
de Filippo, Cesare
Sudmant, Peter H.
Alkan, Can
Fu, Qiaomei
Do, Ron
Rohland, Nadin
Tandon, Arti
Siebauer, Michael
Green, Richard E.
Bryc, Katarzyna
Briggs, Adrian W.
Stenzel, Udo
Dabney, Jesse
Shendure, Jay
Kitzman, Jacob
Hammer, Michael F.
Shunkov, Michael V.
Derevianko, Anatoli P.
Patterson, Nick
Andrés, Aida M.
Eichler, Evan E.
Publication Date:


Subjects / Keywords:
DNA Library Preparation ( local )
Genome Sequence ( local )
Denisovans ( local )
Neandertals ( local )
Archaic Hominins ( local )
serial ( sobekcm )


We present a DNA library preparation method that has allowed us to reconstruct a high-coverage (30×) genome sequence of a Denisovan, an extinct relative of Neandertals. The quality of this genome allows a direct estimation of Denisovan heterozygosity indicating that genetic diversity in these archaic hominins was extremely low. It also allows tentative dating of the specimen on the basis of “missing evolution” in its genome, detailed measurements of Denisovan and Neandertal admixture into present-day human populations, and the generation of a near-complete catalog of genetic changes that swept to high frequency in modern humans since their divergence from Denisovans.
Original Version:
Science, Vol. 338, no. 6104 (2012-10-12).

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