A High-Coverage Genome Sequence from an Archaic Denisovan Individual

Citation

Material Information

Title:
A High-Coverage Genome Sequence from an Archaic Denisovan Individual
Series Title:
Science
Creator:
Meyer, Matthias
Kircher, Martin
Gansauge, Marie-Theres
Li, Heng
Racimo, Fernando
Mallick, Swapan
Schraiber, Joshua G.
Jay, Flora
Prüfer, Kay
de Filippo, Cesare
Sudmant, Peter H.
Alkan, Can
Fu, Qiaomei
Do, Ron
Rohland, Nadin
Tandon, Arti
Siebauer, Michael
Green, Richard E.
Bryc, Katarzyna
Briggs, Adrian W.
Stenzel, Udo
Dabney, Jesse
Shendure, Jay
Kitzman, Jacob
Hammer, Michael F.
Shunkov, Michael V.
Derevianko, Anatoli P.
Patterson, Nick
Andrés, Aida M.
Eichler, Evan E.
Slatkin
Publication Date:
Language:
English

Subjects

Subjects / Keywords:
DNA Library Preparation ( local )
Genome Sequence ( local )
Denisovans ( local )
Neandertals ( local )
Archaic Hominins ( local )
Genre:
serial ( sobekcm )

Notes

Abstract:
We present a DNA library preparation method that has allowed us to reconstruct a high-coverage (30×) genome sequence of a Denisovan, an extinct relative of Neandertals. The quality of this genome allows a direct estimation of Denisovan heterozygosity indicating that genetic diversity in these archaic hominins was extremely low. It also allows tentative dating of the specimen on the basis of “missing evolution” in its genome, detailed measurements of Denisovan and Neandertal admixture into present-day human populations, and the generation of a near-complete catalog of genetic changes that swept to high frequency in modern humans since their divergence from Denisovans.
Original Version:
Science, Vol. 338, no. 6104 (2012-10-12).

Record Information

Source Institution:
University of South Florida Library
Holding Location:
University of South Florida
Rights Management:
This object is protected by copyright, and is made available here for research and educational purposes. Permission to reuse, publish, or reproduce the object beyond the bounds of Fair Use or other exemptions to copyright law must be obtained from the copyright holder.

USFLDC Membership

Aggregations:
University of South Florida
Karst Information Portal

Postcard Information

Format:
serial

printinsert_linkshareget_appmore_horiz

Download Options

close

No images or PDF downloads are available for this resource.


Cite this item close

APA

Cras ut cursus ante, a fringilla nunc. Mauris lorem nunc, cursus sit amet enim ac, vehicula vestibulum mi. Mauris viverra nisl vel enim faucibus porta. Praesent sit amet ornare diam, non finibus nulla.

MLA

Cras efficitur magna et sapien varius, luctus ullamcorper dolor convallis. Orci varius natoque penatibus et magnis dis parturient montes, nascetur ridiculus mus. Fusce sit amet justo ut erat laoreet congue sed a ante.

CHICAGO

Phasellus ornare in augue eu imperdiet. Donec malesuada sapien ante, at vehicula orci tempor molestie. Proin vitae urna elit. Pellentesque vitae nisi et diam euismod malesuada aliquet non erat.

WIKIPEDIA

Nunc fringilla dolor ut dictum placerat. Proin ac neque rutrum, consectetur ligula id, laoreet ligula. Nulla lorem massa, consectetur vitae consequat in, lobortis at dolor. Nunc sed leo odio.