DNA analysis of an early modern human from Tianyuan Cave, China

Citation

Material Information

Title:
DNA analysis of an early modern human from Tianyuan Cave, China
Series Title:
PNAS
Creator:
Fu, Qiaomei
Meyer, Matthias
Gao, Xing
Stenzel, Udo
Burbano, Hernán A.
Kelso, Janet
Pääbo, Svante
Publication Date:
Language:
English

Subjects

Subjects / Keywords:
Ancient DNA ( local )
Human Evolution ( local )
Nuclear Capture Strategy ( local )
Paleogenetics ( local )
Genre:
serial ( sobekcm )

Notes

Abstract:
Hominins with morphology similar to present-day humans appear in the fossil record across Eurasia between 40,000 and 50,000 y ago. The genetic relationships between these early modern humans and present-day human populations have not been established. We have extracted DNA from a 40,000-y-old anatomically modern human from Tianyuan Cave outside Beijing, China. Using a highly scalable hybridization enrichment strategy, we determined the DNA sequences of the mitochondrial genome, the entire nonrepetitive portion of chromosome 21 (∼30 Mbp), and over 3,000 polymorphic sites across the nuclear genome of this individual. The nuclear DNA sequences determined from this early modern human reveal that the Tianyuan individual derived from a population that was ancestral to many present-day Asians and Native Americans but postdated the divergence of Asians from Europeans. They also show that this individual carried proportions of DNA variants derived from archaic humans similar to present-day people in mainland Asia.
Original Version:
PNAS, Vol. 110, no. 6 (2013-12-11).

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University of South Florida Library
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University of South Florida
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This object is protected by copyright, and is made available here for research and educational purposes. Permission to reuse, publish, or reproduce the object beyond the bounds of Fair Use or other exemptions to copyright law must be obtained from the copyright holder.

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