White-nose syndrome is associated with increased replication of a naturally persisting coronaviruses in bats
- Permanent Link:
- White-nose syndrome is associated with increased replication of a naturally persisting coronaviruses in bats
- Series Title:
- Scientific Reportsvolume
- Davy, Christina M.
Donaldson, Michael E.
Turner, James M.
Bollinger, Trent K.
Kyle, Christopher J.
Dorville, Nicole. A. S,-Y.
Kunkel, Emma L.
Norquay, Kaleigh J. O.
Dzal, Yvonne A.
Willis, Craig K. R.
- Springer Nature
- Publication Date:
- Subjects / Keywords:
- Fungal Pathogenesis ( local )
Molecular Ecology ( local )
Virus-Host Interactions ( local )
- serial ( sobekcm )
- Spillover of viruses from bats to other animals may be associated with increased contact between them, as well as increased shedding of viruses by bats. Here, we tested the prediction that little brown bats (Myotis lucifugus) co-infected with the M. lucifugus coronavirus (Myl-CoV) and with Pseudogymnoascus destructans (Pd), the fungus that causes bat white-nose syndrome (WNS), exhibit different disease severity, viral shedding and molecular responses than bats infected with only Myl-CoV or only P. destructans. We took advantage of the natural persistence of Myl-CoV in bats that were experimentally inoculated with P. destructans in a previous study. Here, we show that the intestines of virus-infected bats that were also infected with fungus contained on average 60-fold more viral RNA than bats with virus alone. Increased viral RNA in the intestines correlated with the severity of fungus-related pathology. Additionally, the intestines of bats infected with fungus exhibited different expression of mitogen-activated protein kinase pathway and cytokine related transcripts, irrespective of viral presence. Levels of coronavirus antibodies were also higher in fungal-infected bats. Our results suggest that the systemic effects of WNS may down-regulate anti-viral responses in bats persistently infected with M. lucifugus coronavirus and increase the potential of virus shedding.
- Original Version:
- Scientific Reportsvolume, Vol. 8 (2018-10-19).
- Source Institution:
- University of South Florida Library
- Holding Location:
- University of South Florida
- Rights Management:
- This item is licensed with the Creative Commons Attribution License. This license lets others distribute, remix, tweak, and build upon this work, even commercially, as long as they credit the author for the original creation.
- Resource Identifier:
- K26-05089 ( USFLDC: LOCAL DOI )
k26.5089 ( USFLDC: LOCAL Handle )
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