Pathophysiology of white-nose syndrome in bats: a mechanistic model linking wing damage to mortality

Citation

Material Information

Title:
Pathophysiology of white-nose syndrome in bats: a mechanistic model linking wing damage to mortality
Series Title:
Biology Letters
Creator:
Warnecke, Lisa
Turner, James M.
Bollinger, Trent K.
Misra, Vikram
Cryan, Paul M. et al
Publisher:
The Royal Society Publishing
Publication Date:
Language:
English

Subjects

Subjects / Keywords:
Plasma Electrolytes ( local )
Hypovolemia ( local )
Dehydration ( local )
Hibernation ( local )
Geomyces Destructans ( local )
Genre:
serial ( sobekcm )

Notes

Abstract:
White-nose syndrome is devastating North American bat populations but we lack basic information on disease mechanisms. Altered blood physiology owing to epidermal invasion by the fungal pathogen Geomyces destructans (Gd) has been hypothesized as a cause of disrupted torpor patterns of affected hibernating bats, leading to mortality. Here, we present data on blood electrolyte concentration, haematology and acid–base balance of hibernating little brown bats, Myotis lucifugus, following experimental inoculation with Gd. Compared with controls, infected bats showed electrolyte depletion (i.e. lower plasma sodium), changes in haematology (i.e. increased haematocrit and decreased glucose) and disrupted acid–base balance (i.e. lower CO2 partial pressure and bicarbonate). These findings indicate hypotonic dehydration, hypovolaemia and metabolic acidosis. We propose a mechanistic model linking tissue damage to altered homeostasis and morbidity/mortality.
Original Version:
Biology Letters, Vol. 9, no. 4 (2013-08-23).

Record Information

Source Institution:
University of South Florida Library
Holding Location:
University of South Florida
Rights Management:
This object is protected by copyright, and is made available here for research and educational purposes. Permission to reuse, publish, or reproduce the object beyond the bounds of Fair Use or other exemptions to copyright law must be obtained from the copyright holder.

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