Fatal swine acute diarrhoea syndrome caused by an HKU2-related coronavirus of bat origin


Material Information

Fatal swine acute diarrhoea syndrome caused by an HKU2-related coronavirus of bat origin
Series Title:
Zhou, Peng
Fan, Hang
Lan, Tian
Yang, Xing-Lou
Ahi, Wei-Feng
Zhang, Wei
Zhu, Yan
Zhang, Ya-Wei
Xie, Qing-Mei
Mani, Shailendra
Zheng, Xiao-Shuang
Li, Bei
Li, Jin-Man
Guo, Hua
Pei, Guang-Quian
An, Xiao-Ping
Chen, Jun-Wei
Zhou, Ling
Mai, Kai-Jai
Wu, Zi-Xian
Li, Di
Anderson, Danielle E.
Zhang, Li-Bao
Li, Shi-Yue
Mi, Zhi-Quang
He, Tong-Tong
Cong, Feng
Guo, Peng-Ju
Huang, Ren
Luo, Yun
Xing, Zhen
Chen, Yan-Shan
Sun, Yuan
Li, Juan
Daszak, Peter
Wang, Lin-Fa
Shi, Zheng-Li
Tong, Yi
Publication Date:


Subjects / Keywords:
Viral Epidemiology ( local )
Viral Resevoirs ( local )
serial ( sobekcm )


Cross-species transmission of viruses from wildlife animal reservoirs poses a marked threat to human and animal health1. Bats have been recognized as one of the most important reservoirs for emerging viruses and the transmission of a coronavirus that originated in bats to humans via intermediate hosts was responsible for the high-impact emerging zoonosis, severe acute respiratory syndrome (SARS)2,3,4,5,6,7,8,9,10. Here we provide virological, epidemiological, evolutionary and experimental evidence that a novel HKU2-related bat coronavirus, swine acute diarrhoea syndrome coronavirus (SADS-CoV), is the aetiological agent that was responsible for a large-scale outbreak of fatal disease in pigs in China that has caused the death of 24,693 piglets across four farms. Notably, the outbreak began in Guangdong province in the vicinity of the origin of the SARS pandemic. Furthermore, we identified SADS-related CoVs with 96–98% sequence identity in 9.8% (58 out of 591) of anal swabs collected from bats in Guangdong province during 2013–2016, predominantly in horseshoe bats (Rhinolophus spp.) that are known reservoirs of SARS-related CoVs. We found that there were striking similarities between the SADS and SARS outbreaks in geographical, temporal, ecological and aetiological settings. This study highlights the importance of identifying coronavirus diversity and distribution in bats to mitigate future outbreaks that could threaten livestock, public health and economic growth.
Original Version:
Nature, Vol. 556 (2018-04-04).

Record Information

Source Institution:
University of South Florida Library
Holding Location:
University of South Florida
Rights Management:
This object is protected by copyright, and is made available here for research and educational purposes. Permission to reuse, publish, or reproduce the object beyond the bounds of Fair Use or other exemptions to copyright law must be obtained from the copyright holder.

USFLDC Membership

University of South Florida
Karst Information Portal

Postcard Information



Download Options


No images or PDF downloads are available for this resource.

Cite this item close


Cras ut cursus ante, a fringilla nunc. Mauris lorem nunc, cursus sit amet enim ac, vehicula vestibulum mi. Mauris viverra nisl vel enim faucibus porta. Praesent sit amet ornare diam, non finibus nulla.


Cras efficitur magna et sapien varius, luctus ullamcorper dolor convallis. Orci varius natoque penatibus et magnis dis parturient montes, nascetur ridiculus mus. Fusce sit amet justo ut erat laoreet congue sed a ante.


Phasellus ornare in augue eu imperdiet. Donec malesuada sapien ante, at vehicula orci tempor molestie. Proin vitae urna elit. Pellentesque vitae nisi et diam euismod malesuada aliquet non erat.


Nunc fringilla dolor ut dictum placerat. Proin ac neque rutrum, consectetur ligula id, laoreet ligula. Nulla lorem massa, consectetur vitae consequat in, lobortis at dolor. Nunc sed leo odio.