Fatal swine acute diarrhoea syndrome caused by an HKU2-related coronavirus of bat origin

Citation

Material Information

Title:
Fatal swine acute diarrhoea syndrome caused by an HKU2-related coronavirus of bat origin
Series Title:
Nature
Creator:
Zhou, Peng
Fan, Hang
Lan, Tian
Yang, Xing-Lou
Ahi, Wei-Feng
Zhang, Wei
Zhu, Yan
Zhang, Ya-Wei
Xie, Qing-Mei
Mani, Shailendra
Zheng, Xiao-Shuang
Li, Bei
Li, Jin-Man
Guo, Hua
Pei, Guang-Quian
An, Xiao-Ping
Chen, Jun-Wei
Zhou, Ling
Mai, Kai-Jai
Wu, Zi-Xian
Li, Di
Anderson, Danielle E.
Zhang, Li-Bao
Li, Shi-Yue
Mi, Zhi-Quang
He, Tong-Tong
Cong, Feng
Guo, Peng-Ju
Huang, Ren
Luo, Yun
Xing, Zhen
Chen, Yan-Shan
Sun, Yuan
Li, Juan
Daszak, Peter
Wang, Lin-Fa
Shi, Zheng-Li
Tong, Yi
Publisher:
Nature
Publication Date:
Language:
English

Subjects

Subjects / Keywords:
Viral Epidemiology ( local )
Viral Resevoirs ( local )
Genre:
serial ( sobekcm )

Notes

Abstract:
Cross-species transmission of viruses from wildlife animal reservoirs poses a marked threat to human and animal health1. Bats have been recognized as one of the most important reservoirs for emerging viruses and the transmission of a coronavirus that originated in bats to humans via intermediate hosts was responsible for the high-impact emerging zoonosis, severe acute respiratory syndrome (SARS)2,3,4,5,6,7,8,9,10. Here we provide virological, epidemiological, evolutionary and experimental evidence that a novel HKU2-related bat coronavirus, swine acute diarrhoea syndrome coronavirus (SADS-CoV), is the aetiological agent that was responsible for a large-scale outbreak of fatal disease in pigs in China that has caused the death of 24,693 piglets across four farms. Notably, the outbreak began in Guangdong province in the vicinity of the origin of the SARS pandemic. Furthermore, we identified SADS-related CoVs with 96–98% sequence identity in 9.8% (58 out of 591) of anal swabs collected from bats in Guangdong province during 2013–2016, predominantly in horseshoe bats (Rhinolophus spp.) that are known reservoirs of SARS-related CoVs. We found that there were striking similarities between the SADS and SARS outbreaks in geographical, temporal, ecological and aetiological settings. This study highlights the importance of identifying coronavirus diversity and distribution in bats to mitigate future outbreaks that could threaten livestock, public health and economic growth.
Original Version:
Nature, Vol. 556 (2018-04-04).

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University of South Florida Library
Holding Location:
University of South Florida
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