Surveillance of Bat Coronaviruses in Kenya Identifies Relatives of Human Coronaviruses NL63 and 229E and Their Recombination History

Citation

Material Information

Title:
Surveillance of Bat Coronaviruses in Kenya Identifies Relatives of Human Coronaviruses NL63 and 229E and Their Recombination History
Series Title:
Journal of Virology
Creator:
Tao, Ying
Shi, Mang
Chommanard, Christina
Queen, Krista
Zhang, Jing
Markotter, Wanda
Kuzmin, Ivan V.
Holms, Edward C.
Tong, Suxiang
Publisher:
American Society for Microbiology
Publication Date:
Language:
English

Subjects

Subjects / Keywords:
Chiroptera ( local )
Coronavirus Infections ( local )
Respiratory Tract Infections ( local )
Africa ( local )
Bats ( local )
Coronavirus ( local )
Hcov-229E ( local )
Hcov-NL63 ( local )
Recombination ( local )
Zoonoses ( local )
Genre:
serial ( sobekcm )

Notes

Abstract:
Bats harbor a large diversity of coronaviruses (CoVs), several of which are related to zoonotic pathogens that cause severe disease in humans. Our screening of bat samples collected in Kenya from 2007 to 2010 not only detected RNA from several novel CoVs but, more significantly, identified sequences that were closely related to human CoVs NL63 and 229E, suggesting that these two human viruses originate from bats. We also demonstrated that human CoV NL63 is a recombinant between NL63-like viruses circulating in Triaenops bats and 229E-like viruses circulating in Hipposideros bats, with the breakpoint located near 5′ and 3′ ends of the spike (S) protein gene. In addition, two further interspecies recombination events involving the S gene were identified, suggesting that this region may represent a recombination “hot spot” in CoV genomes. Finally, using a combination of phylogenetic and distance-based approaches, we showed that the genetic diversity of bat CoVs is primarily structured by host species and subsequently by geographic distances.
Original Version:
Journal of Virology, Vol. 91, no. 5 (2017-02-14).

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University of South Florida Library
Holding Location:
University of South Florida
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This object is protected by copyright, and is made available here for research and educational purposes. Permission to reuse, publish, or reproduce the object beyond the bounds of Fair Use or other exemptions to copyright law must be obtained from the copyright holder.

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