Interplay between co-divergence and cross-species transmission in the evolutionary history of bat coronaviruses
- Permanent Link:
- Interplay between co-divergence and cross-species transmission in the evolutionary history of bat coronaviruses
- Series Title:
- Infection, Genetics and Evolution
- Leopardi, Stefania
Holmes, Edward C.
de Benedictis, Paola
- Publication Date:
- Subjects / Keywords:
- Virus ( local )
Bats ( local )
Evolution ( local )
Coronaviruses ( local )
Phylogeny Co-Divergence ( local )
Cross-Species Transmission ( local )
- serial ( sobekcm )
- Coronaviruses (CoVs) have been documented in almost every species of bat sampled. Bat CoVs exhibit both extensive genetic diversity and a broad geographic range, indicative of a long-standing host association. Despite this, the respective roles of long-term virus-host co-divergence and cross-species transmission (host-jumping) in the evolution of bat coronaviruses are unclear. Using a phylogenetic approach we provide evidence that CoV diversity in bats is shaped by both species richness and their geographical distribution, and that CoVs exhibit clustering at the level of bat genera, with these genus-specific clusters largely associated with distinct CoV species. Co-phylogenetic analyses revealed that cross-species transmission has been more common than co-divergence across coronavirus evolution as a whole, and that cross-species transmission events were more likely between sympatric bat hosts. Notably, however, an analysis of the CoV RNA polymerase phylogeny suggested that many such host-jumps likely resulted in short-term spill-over infections, with little evidence for sustained onward transmission in new co-roosting host species.
- Original Version:
- Infection, Genetics and Evolution, Vol. 58 (2018-03-01).
- Source Institution:
- University of South Florida Library
- Holding Location:
- University of South Florida
- Rights Management:
- This object is protected by copyright, and is made available here for research and educational purposes. Permission to reuse, publish, or reproduce the object beyond the bounds of Fair Use or other exemptions to copyright law must be obtained from the copyright holder.
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