Prevalence and Genetic Diversity of Coronaviruses in Bats from China

Citation

Material Information

Title:
Prevalence and Genetic Diversity of Coronaviruses in Bats from China
Series Title:
Journal of Virology
Creator:
Tang, X. C.
Zhang, J. X.
Zhang, S. Y.
Wang, P.
Fan, X. H.
Li, L. F.
Li, G.
Dong, B. Q.
Liu, W.
Cheung, C. L.
Xu, K. M.
Song, W. J.
Vijaykrishna, D.
Poon, L. L. M.
Peiris, J. S. M.
Smith, G. J. D.
Chen, H.
Guan, Y.
Publisher:
American Society for Microbiology
Publication Date:
Language:
English

Subjects

Subjects / Keywords:
Prevalence ( local )
Genetic Diversity ( local )
Coronaviruses ( local )
Bats ( local )
China ( local )
Genre:
serial ( sobekcm )

Notes

Abstract:
Coronaviruses can infect a variety of animals including poultry, livestock, and humans and are currently classified into three groups. The interspecies transmissions of coronaviruses between different hosts form a complex ecosystem of which little is known. The outbreak of severe acute respiratory syndrome (SARS) and the recent identification of new coronaviruses have highlighted the necessity for further investigation of coronavirus ecology, in particular the role of bats and other wild animals. In this study, we sampled bat populations in 15 provinces of China and reveal that approximately 6.5% of the bats, from diverse species distributed throughout the region, harbor coronaviruses. Full genomes of four coronavirues from bats were sequenced and analyzed. Phylogenetic analyses of the spike, envelope, membrane, and nucleoprotein structural proteins and the two conserved replicase domains, putative RNA-dependent RNA polymerase and RNA helicase, revealed that bat coronaviruses cluster in three different groups: group 1, another group that includes all SARS and SARS-like coronaviruses (putative group 4), and an independent bat coronavirus group (putative group 5). Further genetic analyses showed that different species of bats maintain coronaviruses from different groups and that a single bat species from different geographic locations supports similar coronaviruses. Thus, the findings of this study suggest that bats may play an integral role in the ecology and evolution of coronaviruses.Coronaviruses (CoVs) are enveloped, single-stranded, positive-sense RNA viruses (4). Based on serological and genetic features, coronaviruses are classified into three groups (14). These viruses infect various species of poultry, livestock, and pets and also humans, causing acute and chronic respiratory, enteric, hepatic, and central nervous system diseases (45). Prior to the outbreak of severe acute respiratory syndrome (SARS), most of our knowledge regarding coronaviruses resulted from investigations associated with animal health.
Original Version:
Journal of Virology, Vol. 80, no. 15 (2006-07-12).

Record Information

Source Institution:
University of South Florida Library
Holding Location:
University of South Florida
Rights Management:
This object is protected by copyright, and is made available here for research and educational purposes. Permission to reuse, publish, or reproduce the object beyond the bounds of Fair Use or other exemptions to copyright law must be obtained from the copyright holder.

USFLDC Membership

Aggregations:
University of South Florida
Karst Information Portal

Postcard Information

Format:
serial

printinsert_linkshareget_appmore_horiz

Download Options

close

No images or PDF downloads are available for this resource.


Cite this item close

APA

Cras ut cursus ante, a fringilla nunc. Mauris lorem nunc, cursus sit amet enim ac, vehicula vestibulum mi. Mauris viverra nisl vel enim faucibus porta. Praesent sit amet ornare diam, non finibus nulla.

MLA

Cras efficitur magna et sapien varius, luctus ullamcorper dolor convallis. Orci varius natoque penatibus et magnis dis parturient montes, nascetur ridiculus mus. Fusce sit amet justo ut erat laoreet congue sed a ante.

CHICAGO

Phasellus ornare in augue eu imperdiet. Donec malesuada sapien ante, at vehicula orci tempor molestie. Proin vitae urna elit. Pellentesque vitae nisi et diam euismod malesuada aliquet non erat.

WIKIPEDIA

Nunc fringilla dolor ut dictum placerat. Proin ac neque rutrum, consectetur ligula id, laoreet ligula. Nulla lorem massa, consectetur vitae consequat in, lobortis at dolor. Nunc sed leo odio.