Full-length genome sequences of two SARS-like coronaviruses in horseshoe bats and genetic variation analysis

Citation

Material Information

Title:
Full-length genome sequences of two SARS-like coronaviruses in horseshoe bats and genetic variation analysis
Series Title:
JOURNAL OF GENERAL VIROLOGY
Creator:
Ren, Wuze
Li, Wendong
Yu, Meng
Hao, Pei
Zhang, Yuan
Zhou, Peng
Zhang, Shuyi
Zhao, Guoping
Zhong, Yang
Wang, Shengyue
Wang, Lin-Fa
Shi, Zhengli
Publisher:
Microbiology Society
Publication Date:
Language:
English

Subjects

Subjects / Keywords:
Full-Length Genome Sequences ( local )
Genome Sequences ( local )
Sars ( local )
Coronavirus ( local )
Horseshoe Bats ( local )
Bats ( local )
Genetic Variation ( local )
Genetic Variation Analysis ( local )
Genre:
serial ( sobekcm )

Notes

Abstract:
Bats were recently identified as natural reservoirs of SARS-like coronavirus (SL-CoV) or SARS coronavirus-like virus. These viruses, together with SARS coronaviruses (SARS-CoV) isolated from human and palm civet, form a distinctive cluster within the group 2 coronaviruses of the genus Coronavirus, tentatively named group 2b (G2b). In this study, complete genome sequences of two additional group 2b coronaviruses (G2b-CoVs) were determined from horseshoe bat Rhinolophus ferrumequinum (G2b-CoV Rf1) and Rhinolophus macrotis (G2b-CoV Rm1). The bat G2b-CoV isolates have an identical genome organization and share an overall genome sequence identity of 88–92 % among themselves and between them and the human/civet isolates. The most variable regions are located in the genes encoding nsp3, ORF3a, spike protein and ORF8 when bat and human/civet G2b-CoV isolates are compared. Genetic analysis demonstrated that a diverse G2b-CoV population exists in the bat habitat and has evolved from a common ancestor of SARS-CoV.
Original Version:
JOURNAL OF GENERAL VIROLOGY, Vol. 87, no. 11 (2006-11-01).

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University of South Florida Library
Holding Location:
University of South Florida
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This object is protected by copyright, and is made available here for research and educational purposes. Permission to reuse, publish, or reproduce the object beyond the bounds of Fair Use or other exemptions to copyright law must be obtained from the copyright holder.

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