ORF8-Related Genetic Evidence for Chinese Horseshoe Bats as the Source of Human Severe Acute Respiratory Syndrome Coronavirus

Citation

Material Information

Title:
ORF8-Related Genetic Evidence for Chinese Horseshoe Bats as the Source of Human Severe Acute Respiratory Syndrome Coronavirus
Series Title:
The Journal of Infectious Diseases
Creator:
Zhiquiang, Wu
Yang, Li
Ren, Xianwen
Zhang, Junpeng
Yang, Fan
Zhang, Shuyi
Jin, Qi
Publisher:
Oxford Academic
Publication Date:
Language:
English

Subjects

Subjects / Keywords:
Severe Acute Respiratory Syndrome Coronavirus ( local )
Origin ( local )
Bats ( local )
Orf8 ( local )
Genre:
serial ( sobekcm )

Notes

Abstract:
Several lineage B betacoronaviruses termed severe acute respiratory syndrome (SARS)–like CoVs (SL-CoVs) were identified from Rhinolophus bats in China. These viruses are characterized by a set of unique accessory open reading frames (ORFs) that are located between the M and N genes. Among unique accessory ORFs, ORF8 is most hypervariable. In this study, the ORF8s of all SL-CoVs were classified into 3 types, and, for the first time, it was found that very few SL-CoVs from Rhinolophus sinicus have ORF8s that are identical to that of human SARS-CoV. This finding provides new genetic evidence for Chinese horseshoe bats as the source of human SARS-CoV.
Original Version:
The Journal of Infectious Diseases, Vol. 213, no. 4 (2016-02-15).

Record Information

Source Institution:
University of South Florida Library
Holding Location:
University of South Florida
Rights Management:
This object is protected by copyright, and is made available here for research and educational purposes. Permission to reuse, publish, or reproduce the object beyond the bounds of Fair Use or other exemptions to copyright law must be obtained from the copyright holder.

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