Isolation and Characterization of a Novel Bat Coronavirus Closely Related to the Direct Progenitor of Severe Acute Respiratory Syndrome Coronavirus

Citation

Material Information

Title:
Isolation and Characterization of a Novel Bat Coronavirus Closely Related to the Direct Progenitor of Severe Acute Respiratory Syndrome Coronavirus
Series Title:
Journal of Virology
Creator:
Yang, Xing-Lou
Hu, Ben
Wang, Bo
Wang, Mei-Niang
Zhang, Quian
Zhang, Wei
Wu, Li-Jun
Ge, Xing-Yi
Zhang, Yun-Zhi
Daszak, Peter
Wang, Lin-Fa
Shi, Zheng-Li
Publisher:
American Society for Microbiology
Publication Date:
Language:
English

Subjects

Subjects / Keywords:
Isolation ( local )
Characterization ( local )
Novel Bat Coronavirus ( local )
Bat ( local )
Coronavirus ( local )
Sars ( local )
Genre:
serial ( sobekcm )

Notes

Abstract:
We report the isolation and characterization of a novel bat coronavirus which is much closer to the severe acute respiratory syndrome coronavirus (SARS-CoV) in genomic sequence than others previously reported, particularly in its S gene. Cell entry and susceptibility studies indicated that this virus can use ACE2 as a receptor and infect animal and human cell lines. Our results provide further evidence of the bat origin of the SARS-CoV and highlight the likelihood of future bat coronavirus emergence in humans.
Original Version:
Journal of Virology, Vol. 90, no. 6 (2016-02-26).

Record Information

Source Institution:
University of South Florida Library
Holding Location:
University of South Florida
Rights Management:
This object is protected by copyright, and is made available here for research and educational purposes. Permission to reuse, publish, or reproduce the object beyond the bounds of Fair Use or other exemptions to copyright law must be obtained from the copyright holder.

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University of South Florida
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serial

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