Bat severe acute respiratory syndrome-like coronavirus ORF3b homologues display different interferon antagonist activities


Material Information

Bat severe acute respiratory syndrome-like coronavirus ORF3b homologues display different interferon antagonist activities
Series Title:
Journal of general virology
Zhou, Peng
Li, Hongxia
Wang, Hanzhong
Wang, Lin-Fa
Shi, Zhengli
Microbiology Society
Publication Date:
Physical Description:
1 online resource


Subjects / Keywords:
Coronaviruses ( lcsh )
SARS (Disease) ( lcsh )
Bats -- Viruses ( lcsh )
serial ( sobekcm )


The ORF3b protein of severe acute respiratory syndrome coronavirus (SARS-CoV) has a nuclear localization signal (NLS) at its C terminus and antagonizes interferon (IFN) function by modulating the activity of IFN regulatory factor 3 (IRF3). SARS-like coronaviruses (SL-CoVs) found in bats share an identical genome organization and high sequence identity for most of their gene products. In this study, ORF3b homologues were identified from three bat SL-CoV strains. These ORF3b homologues were C-terminally truncated and lacked the C-terminal NLS of SARS-CoV. IFN antagonist activities analysis demonstrated that one SL-CoV ORF3b still possessed IFN antagonist and IRF3-modulating activities. These results indicate that different ORF3b proteins display different IFN antagonist activities and this function is independent of the protein’s nuclear localization, suggesting a potential link between bat SL-CoV ORF3b function and viral pathogenesis.
Original Version:
Volume 93

Record Information

Source Institution:
University of South Florida
Holding Location:
University of South Florida
Rights Management:
All applicable rights reserved by the source institution and holding location.
Resource Identifier:
K26-05438 ( USFLDC DOI )

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University of South Florida
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