Title Surveillance of Bat Coronaviruses in Kenya Identifies Relatives of Human Coronaviruses NL63 and 229E and Their Recombination History
Abstract
Bats harbor a large diversity of coronaviruses (CoVs), several of which are related to zoonotic pathogens that cause ... Publication Date
2016-12-04
Holding Location
University of South Florida
Language
English
Creator
Tao, Ying Shi, Mang Chommanard, Christina Queen, Krista Zhang, Jing Markotter, Wanda Kuzmin, Ivan V. Holmes, Edward C. Tonga, Suxiang Source Institution
University of South Florida Library
Subjects / Keywords
Africa Bats Coronavirus Hcov-229E Hcov-NL63 Recombination Zoonoses Series Title
Journal of Virology Aggregation
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serial
Serial Info
Journal of Virology, Vol. 91, no. 5 (2016-12-04).
This object is protected by copyright, and is made available here for research and educational purposes. Permission to reuse, publish, or reproduce the object beyond the bounds of Fair Use or other exemptions to copyright law must be obtained from the copyright holder.
Surveillance of Bat Coronaviruses in Kenya Identifies Relatives of Human Coronaviruses NL63 and 229E and Their Recombination History
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Permanent Link:
https://digital.lib.usf.edu/SFS0069660/00001
Material Information
Title:
Surveillance of Bat Coronaviruses in Kenya Identifies Relatives of Human Coronaviruses NL63 and 229E and Their Recombination History Series Title:
Journal of Virology
Creator:
Tao, Ying
Shi, Mang
Chommanard, Christina
Queen, Krista
Zhang, Jing
Markotter, Wanda
Kuzmin, Ivan V.
Holmes, Edward C.
Tonga, Suxiang
Publication Date:
2016-12-04 Language:
English
Subjects
Subjects / Keywords:
Africa ( local )
Genre:
serial ( sobekcm )
Notes
Abstract:
Bats harbor a large diversity of coronaviruses (CoVs), several of which are related to zoonotic pathogens that cause severe disease in humans. Our screen- ing of bat samples collected in Kenya from 2007 to 2010 not only detected RNA from several novel CoVs but, more significantly, identified sequences that were closely related to human CoVs NL63 and 229E, suggesting that these two human vi- ruses originate from bats. We also demonstrated that human CoV NL63 is a recom- binant between NL63-like viruses circulating in Triaenops bats and 229E-like viruses circulating in Hipposideros bats, with the breakpoint located near 5= and 3= ends of the spike (S) protein gene. In addition, two further interspecies recombination events involving the S gene were identified, suggesting that this region may repre- sent a recombination “hot spot†in CoV genomes. Finally, using a combination of phylogenetic and distance-based approaches, we showed that the genetic diversity of bat CoVs is primarily structured by host species and subsequently by geographic distances. Original Version:
Journal of Virology, Vol. 91, no. 5 (2016-12-04).
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Source Institution:
University of South Florida Library Holding Location:
University of South Florida
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This object is protected by copyright, and is made available here for research and educational purposes. Permission to reuse, publish, or reproduce the object beyond the bounds of Fair Use or other exemptions to copyright law must be obtained from the copyright holder.
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