Genetic analysis of cavefish reveals molecular convergence in the evolution of albinism

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Title:
Genetic analysis of cavefish reveals molecular convergence in the evolution of albinism
Series Title:
Nature Genetics
Creator:
Protas, Meredith E.
Hersey, Candace
Kochanek, Dawn
Zhou, Yi
Wilkens, Horst
Jeffery, William R.
Zon, Leonard I
Borowsky, Richard
Tabin, Clifford J.
Publisher:
Springer Nature
Publication Date:
Language:
English

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serial ( sobekcm )

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Abstract:
The genetic basis of vertebrate morphological evolution has traditionally been very difficult to examine in naturally occurring populations. Here we describe the generation of a genome-wide linksage map to allow quantitative trait analysis of evolutionarily derived morphologies in the Mexican cave tetra, a species that has, in a series of independent caves, repeatedly evolved specialized characteristics adapted to a unique and well-studied ecological environment. We focused on the trait of albinism and discovered that it is linksed to Oca2, a known pigmentation gene, in two cave populations. We found different deletions in Oca2 in each population and, using a cell-based assay, showed that both cause loss of function of the corresponding protein, OCA2. Thus, the two cave populations evolved albinism independently, through similar mutational events.
Original Version:
Nature Genetics, Vol. 38 (2005-12-11).

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University of South Florida Library
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University of South Florida
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This object is protected by copyright, and is made available here for research and educational purposes. Permission to reuse, publish, or reproduce the object beyond the bounds of Fair Use or other exemptions to copyright law must be obtained from the copyright holder.

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