Keeping the blood flowing—plasminogen activator genes and feeding behavior in vampire bats

Citation

Material Information

Title:
Keeping the blood flowing—plasminogen activator genes and feeding behavior in vampire bats
Series Title:
Naturwissenschaften
Creator:
Tellgren-Roth, Åsa
Dittmar, Katharina
Massey, Steven E.
Kemi, Cecilia
Tellgren-Roth, Christian
Savolainen, Peter
Lyons, Leslie A.
Liberles, David A.
Publisher:
Springer Nature
Publication Date:
Language:
English

Subjects

Subjects / Keywords:
Species Adaptation ( local )
Positive Selection ( local )
Domain Evolution ( local )
Gene Duplication ( local )
Ecological Niche ( local )
Genre:
serial ( sobekcm )

Notes

Abstract:
The blood feeding vampire bats emerged from New World leaf-nosed bats that fed on fruit and insects. Plasminogen activator, a serine protease that regulates blood coagulation, is known to be expressed in the saliva of Desmodus rotundus (common vampire bat) and is thought to be a key enzyme for the emergence of blood feeding in vampire bats. To better understand the evolution of this biological function, we studied the plasminogen activator (PA) genes from all vampire bat species in light of their feeding transition to bird and subsequently mammalian blood. We include the rare species Diphylla ecaudata and Diaemus youngi, where plasminogen activator had not previously been studied and demonstrate that PA gene duplication observed in Desmodus is not essential to the vampire phenotype, but relates to the emergence of predominant mammalian blood feeding in this species. Plasminogen activator has evolved through gene duplication, domain loss, and sequence evolution leading to change in fibrin-specificity and susceptibility to plasminogen activator inhibitor-1. Before undertaking this study, only the four plasminogen activator isoforms from Desmodus were known. The evolution of vampire bat plasminogen activators can now be linksed phylogenetically to the transition in feeding behavior among vampire bat species from bird to mammalian blood.
Original Version:
Naturwissenschaften, Vol. 96, no. 1 (2008-09-13).

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University of South Florida Library
Holding Location:
University of South Florida
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